Thursday , August 18 2022

A new study will solve the long-lasting mystery of congenital immunity



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New South West biochemists and Progressive Prize Laureate Dr Jianzhiang James, Chen's new research, answers a long-standing question in the field of congenital immune system.

Scientists are surprised that for a long time NLRP3 of a single protein can inflate in response to a wide range of unconventional stimuli.

Professor of Molecular Biology and Director of the Center for Inflammatory Studies at the South West Center of UT Dr. Chen, received a breakthrough in Life Science in this month to identify DNA sensitive enzymes for DGA (cyclic GMP-AMP synthesis). cellular immune response.

Published in this study today Nature, Dr. Chen studied the pathways of the immune system, including the protein NLRP3, which contributes to the cellular set of the multiprotine complex called inflammation. In response to a large number of malignant agents from toxins to cholesterol crystals, inflammable gas causes the death of inflammatory cells or the Greek word piro that causes pyro-derived pyrophosis. Inflammation enhances the production of such substances as the interleukin that aids the immune system's immune response.

Furthermore, NLRP3 is inflamed by a group of autoinfluorescritic diseases called criopyrine-related syndromes (CAPS), which include family-born soy or autoinfective syndrome (FCAS), gastric and Alzheimer's disease-induced cerebral inflammation.

"How long has it been so long in this area that many different agents, such as NLRP3, do not share chemical or structural similarities?" Says Joche Chen, Howard Hughes Medical Institute Investigator, George L. McGregor is a professor at the Department of Biomedical Sciences as well as a professor at the Center for Host Genetics in South-West. "These studies offer a new path to the therapeutic approach to NLRP3 for the treatment of inflammatory diseases."

Using a combination of biochemical, immigration and genetic views, Dr. Chen and Dr. Juke Chen, a leading author and researcher of the researcher, have identified previously unknown structural changes in cells.

They stimulated various cellular organelles to take the Trans-Golgi (TGN) line into bubbles or fluidized bristles. These bubbles have a special lipid component (PI4P) that binds to a specific region of NLRP3. This contact causes a number of events that can lead to inflammation.

"The uniqueness of NLRP3 inflammation can be caused by many stimuli," says Dr. Chen. "The study found that instead of detecting malignant agents, NLRP3 detects the structural changes of various agents leading to cellular inflammation. The activation of HPR3 indicates the" protective pattern "used to combat the plants by controlling target hosts called pathogenic-induced-modified-self-assertion various threats.

"As a result, NLRP3 indirectly experiences many pathogenic and dangerous molecules," he said.

Source:

https://www.utsouthwestern.edu/newsroom/articles/year-2018/innate-immunity.html

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