Saturday , April 1 2023

Patients with HIV can change the daily tablets daily


Patients with HIV may change the usual treatment with the antiretroviral tablets every month by injecting them into the abdomen. According to the head of the infection department, the emergence of this new method can be "one and a half year or one and a half years" after approval by the European Medicines Agency (EMA). Jose Ramon Aribas, University of La Paz.

The expert is taking part in the presentation of the SI INDIVIHDUALITY Symposium, organized by Janssen Pharmaceutical Company in Madrid this Friday, where more than 250 experts will participate in the analysis of the latest achievements in basic and clinical trials with HIV / AIDS. a week ago at a conference on this subject, held a conference on Retroviruses and Opportunistic Infections (CROI).

Among the novelties known during this appointment, two tests have demonstrated that it is effective to control the viral load of HIV compared to modern antiretroviral therapy, with two intravenous drug injections each month. they are administered daily by tablets.

The two lawsuits were submitted to the European regulator and the Food and Drug Administration of the United States (FDA), which may be available in the near future upon their decision.

"These delayed release drugs offer a new method for the first generation of antiretroviral drugs, which is less toxic. In the next stage injections can be two, four or six months, but the turn of the corner is every month ", – said Aribas.

Hosped Mallolas, head of Barcelona's HIV / AIDS division, said he would be "a great tool" for people with HIV, but "not every one is dependent on their clinical condition." "There will be great improvements for a large percentage of patients because they do not want to take pills everyday," he said, noting that he or she chose the patient.

New infections do not go down

On the other hand, Mallolas assessed the current situation in the fight against HIV. "There are two novelties: the good antiretroviral effect, they have a long-lasting and unspecified viral load, which means you can not send a virus," he said first.

Nevertheless, she regretted that despite these and other advances, nearly 3,000 new infections could not be reduced annually. "Numbers are like ten years ago, and we do not do well," he added. In this regard, Arribas does not know that up to 25 per cent of the infected in our country.

"It is not easy to diagnose them because the whole nation should undergo testing." In Spain, there are preventive measures such as Preventive Prevention (PREP) that have not been used in Spain, but have a good outcome in Australia or Canada to reduce new diagnosis. Spain will be forgiven in this aspect ", – said the researcher at La Paz hospital.

On the way to recovery

Arribas noted another need to fight HIV: vaccine. In his opinion, it is difficult to manage the current epidemic in this way. "We do not have an effective vaccine but we have a lot of research on it, it's a key element in the epidemic, and we're trying to achieve it for many years, and it remains our big scientific goal," he said.

Experts have also used the next challenge, despite the fact that HIV can be "cured". In this regard, the presentation of the symposium was conducted by a research fellow at the Cathy Research Institute of Continuing Education (ICREA), researcher at the University of Iowa, Javier Martínez-Picado, and a member of the research group that has been remedied for 1.5 years without antiretroviral treatment.

A London patient passed the stem cell transplant to treat lymphoma. The donor was a mutation (CCR5delta32) that prevented HIV from infecting the virus. After 16 months, doctors decided to stop antiretroviral therapy, and HIV did not appear again after 18 months.

According to Martinez-Picdo, this approach, which proves that a patient with HIV has a hemological problem (such as a lymphoma), appears in several European countries and three patients in Andalusia, Catalonia and Madrid. . "However, it should be noted that the virus lasted for nine months after the breakdown of the therapy, so we have to be very careful," he said.

According to the specialist, the scientific invitation is "treatment". "This requires new therapeutic goals that can be minimized if the virus is lost from the body. We need to find the "awakening" molecules of the virus to destroy the immune system, "he said. .

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