Monday , June 5 2023

The protein makes you distort – ScienceDaily


Asymmetry plays an important role in biology on every scale: the DNA helix, the human heart's left, the desire to use our right or left … The team of the Institute of Biology, CNRS / Inserm / Université Côte d'Azur, collaborates with colleagues from the University of Pennsylvania, how one protein produces a spiral motion in another molecule. Through domino effect, these cells, organisms and, in fact, cause rotational behavior of the entire body. This study will be published in the journal Science November 23, 2018.

Our world is fundamentally asymmetric: the DNA double spiral, the asymmetric division of the stomach cells, or the human heart is on the left … But how does this asymmetry come from and they are interconnected?

Inserm and Université Cote d'Azur researchers led by CNRS researcher Stefan Noselly at Biology Valrose Institute have been exploring left-handed asymmetry for years to solve these secrets. Biologists have identified the first gene-control asymmetry on one of the favorable model organisms of biology, the Drosophila on the general fruition. Recently, the team has shown that this gene proves the role of vertebrate animals: the protein it produces, Myosin 1D, controls the rotation or rotation of the organs in one direction.

In this new study, researchers have created Myosin 1D as usual symmetrical organs of Drosophila, such as respiratory tract. It's great that at all levels is enough to cause asymmetry: deformation of the behavior of the helicopter locomotive between the deformed cells, the tracheal around them, the body rotation and the flight larvae. This new asymmetry is always evolving in one direction.

Biochemists from the University of Pennsylvania have also helped the project to determine the effect of this cascade effect: Myosin 1D on a glass tray linked the cytoskeleton component (cell hip), in particular the actin. They found that the interaction of two proteins brought the actin to the spiral.

Apart from its roles in the left asymmetry of dosophila and vertebrates, Myosin 1D is a unique protein able to cause asymmetry on a molecular basis and then domino effect. cell, tissue and behavior. These results suggest a possible mechanism for sudden emergence of new morphological characteristics in the process of evolution, for example, the snake's torsion. Thus, Myosin 1D possesses all the necessary characteristics of the novelty, as its expression is sufficient only to generate torsion on all scales.

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