Friday , February 3 2023

From the Anglo-Pisa study, new prospects for antibiotic treatment



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In vivo antitumor effects doxycycline, an antibiotic used to treat the tetracycline class and usually treat skin acids has recently been published in an international journal Boundaries on Oncology, which has led to the potential use of antibiotics in the treatment of breast cancer. In addition to bacterial killing, antibiotics have a destructive effect on the "power plants" of the cell, which is rich in neoplastic plant cells responsible for the occurrence of mitochondria, cancer and local recurrence. therapy and afraid of distant metastases.

The research was conducted by the research team of the professor Antonio Giuseppe Nakcatoato, Director of Pathological Anatomy Department Aoup 1, with the doctor Christian Sturen, Anatomologist and student of the School of Philosophy of Ethyl-National Clinical Sciences at the University of Pisa, researchers at the University of Salford, Manchester, and the AOSP Synology Center and the Pysan Science Foundation.

Clinical studies were conducted 15 women affected early carcinoma in breast and showed a significant decrease in the number of neoplastic stem cells (about 40%) after treatment with 14-day antibiotics. Researchers from the University of Salford, Professor Michael L. Lysanti Coordinators Recognize that antibiotic doxycycline can eliminate neoplastic cells of eight different types of cancer, long-term breast cancer research in the "in vitro" cancer models. These in vitro studies have laid the foundation for the early clinical trials of doxycycline in patients with early stage breast cancer and, therefore, for candidates for surgical treatment. The trial was held Aoup Senology Center It was headed by Professor Manuel Roncella.

In general, doxycycline was injected into 9 patients (experimental access), and additional 6 patients were included as observers; the first one for the antibiotic i 14 days 200 mg in the previous daily dose; and on the other hand, directly undergoing surgical treatment. In clinical hermetic weapons, many biological symptoms (stomatitis, mitochondria mass, cell proliferation, etc.) were compared and studied exclusively by antibiotic therapy and after comparative inebriation of tumor tissues of relative inhibitory anesthetic surgery.

After treatment with dissicicillin, the tumor of the experimental hands showed a significant reduction in the tolerance of the patients, 17.65 and 66.67%. Similar data was also observed with the cell biomarker of the second form.

The results from this pilot study show that myoclastic cells select large amounts of proteins due to mitochondrial metabolism. If it is possible to inhibit mitochondrial metabolism, then neoplastic stem cells can be eliminated. Enables new patients to receive in the coming months this is the first very promising outcome.

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