The team of researchers achieved the functional recovery of the mice through cerebral stroke after implanting stem cells encapsulated in silk fibrous hydrogels.
Alberto Iglesias Fraga
Mexico City, November 10 (TICbeat / SinEmbargo) .- Imagine the following: some scientists are implanting encapsulated stem cells a shameless biomaterials and fully bioavailability of functional healing of people suffering from myocardial infarction, nervous tissue correction damaged and avoided damage.
It looks like science fiction, but nothing is really true. Researchers at the University of Madrid (UCM), Kajal Institute and the San Carlos Clinic Hospital are the researchers at the Center for Biomedical Technology at the University of Madrid, Polytechnic University (UPM): Mice with cerebral stroke after implantation encapsulated stem cells hydrogels silk fibroin.
Different types of neurological diseases cause permanent body and cognitive disability. Our nervous system has limited capability to recover from injuries as it can cause stroke and traumatic brain injury, and on the other hand, in neurodegenerative diseases Alzheimer's disease or Parkinson's then there is a gradual deterioration of our brain function. Cellular cell therapy has been a major strategic step in treating these diseases, due to their therapeutic potential for the protection and recovery of damage to the brain. However, transplantation of the stem cells is difficult, with the exception of post-transplantation of the brain, which is a major obstacle to maximum therapeutic effectiveness.
In order to overcome this obstacle, these Spanish scientists have developed a new bioengineering strategy to restore the tissue of the injured brain. To do this, they used mice with cerebral infarction, which had mesenchymal origin cells damaged and completely bioavailability in biomaterials: encapsulated in silk fibrogen. After treatment, the mice dramatically improved their sensory and motor abilities deeply after brain damage. Moreover, using electrophysiological methods, researchers have accompanied the phenomenon of brain reorganization in areas close to the zone of functional improvement. An important aspect of the study is that silk fibroids significantly increase the survival of brain implantated stem cells, which inhibits the further prolonged postoperative cerebral stroke.
According to CTB UPM researcher Daniel Gonzalez Nieto, "these results are a way of treating neurological disorders, a new type of therapy based on vehicle-based fibroids, and thus enhances the therapeutic performance and the functional improvement of patients."
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