Pain has been supposed to be activated by free nerve endings without end organs in the skin. It causes suffering and results in substantial costs for society.
Almost one person in each of five experiences. In any case, the sensitivity to pain is also required for survival, and it has a protective function. It gives you a reflection of how to react to the problem.
Scientists at Karolinska Institutet in Sweden have found another sensory organ that can distinguish painful mechanical damage, for example, pricks and impacts.
The newly discovered organ under the skin is sensitive to hazardous environmental irritation. It consists of glio cells with many long protrusions and which collectively go to make a mesh-like organ inside the skin. This organ is sensitive to painful mechanical damage, for example, pricks and pressure.
The organ is afflicted with pain in the skin, and its activation leads to electrical impulses in the nervous system.
The organ is made of cells that are highly sensitive to mechanical stimuli, which explain how painful pinpricks and pressure are. During the experiments, scientists were able to block the organ.
Patrick Ernfors, professor at Karolinska Institutet's Department of Biochemistry and Biophysics and Chief investigator for the study, said: "Our study shows that the sensitivity to pain does not occur in the skin's nerve fibers, but also this recently-discovered pain-sensitive organ The discovery changes our understanding of the cellular mechanisms of physical sensation, and it may be of significance in the understanding of chronic pain. "
The discovery is published in science journal Science.