"This method does not allow any progress and can never be the basis for therapy." Together with these words, The Natural Medicine Magazine denied Don Cleveland's manuscript in 2005. Professor describes the work medication and Neurology of the University of California, San Diego New Method for the Treatment of Degenerative Nervous Diseases Amyotrophic Lateral Sclerosis (ALS) is a disease that has been suffered by world-renowned physicist Stephen Hawking. Cleveland and his team, in experiments with mice called designer DNA, have significantly slowed the course of the disease.
Today, 13 years later, the new therapy developed by Don Cleveland has reached the limit for patients. Several clinical studies with DNA designer preparations are being conducted. And this is not only the genus of ALS, but also genetically ill, such as Huntington's disease, Alzheimer's or other neurodegenerative diseases such as frontotemporal dementia.
The principle is always the same: designer DNA drug antisense oligonucleotides (ACS), which minimize the production of the disease-causing protein. For example, in the nervous cells of Alzheimer's or the front-line dementia, protein is the "mountain" that causes cell death.
DNA is used to mitigate the muscle in the market
Other nervous system diseases such as spine muscle atrophy (SMA) and new DNA medicine have been reported. In this hereditary disease, those called motor neurons do not work properly, which is the nerve cells that control the muscles of the muscles. The reason is the fault. As a result, the muscles in the body deteriorate due to the lack of motor stimulation.
Newborn babies born with the most severe type of KMA can not sit, head or rotate; they fight for breathing and swallowing; usually they will not survive the second birthday. Last year, the first mortality rate was a hereditary disease. The Cleveland-based principle, Spinraza (Biogen's manufacturer), slows down the massive mass of muscles, the normal development of some of the treated children.
ALS, Stephen Hawking suffers from the illness, which can be treated soon. Picture: Getty
It takes a few years to see if the success of new DNA Drugs in ALS, Alzheimer's & other neurodegenerative diseases is so great that noise can rise. They always give you hope. For example, Huntington. The first clinical test was so promising that Roche pharmaceutical company acquired development and marketing rights for therapy in Basel in April from Ionis, California's biotech company. By the end of 2018 or early 2019, Rosh plans to launch a large clinical trial. "We know drugs are safe," says Cleveland, "and I hope the patients will benefit.
It looks like Cleveland's persistence. Several years ago, he confused the idea of paralyzing active or inactive active genes with DNA fragments, reducing protein production, which at our personal meeting was held at the Swiss Nomis Foundation in October. She admits she does not work in cell biology textbooks. "I think the nerve cells do not read textbooks," he wrote, repeating anecdote that he had mentioned before he denied the "Natural Medicine" article.
In the dissertation "Tau" protein
Cleveland laugh well when San Diego develops a technique that allows it to treat many other illnesses in the Louisiana Illness Research Institute and its team. Glioblastoma, a brain tumor up to the present. Cleveland has earned a Progressive Award for $ 3 million last year for this breakthrough. And now the price of the Nomis fund. At the award ceremony, Cleveland was duly approved. "You're the first to be able to treat neurodegenerative diseases in the clinic," says Alzheimer's researcher, Doctor of Economics, University of Munich. Christian Haas.
Research is not always a profession for Don Cleveland. "I always wanted to be a scientist," she says. "I can not remember anything." Cleveland grew up with two brothers near the Mexican border in New Mexico. Her father studied physics at a local college, and one of her sisters today is the same in chemistry. Cleveland first studied physics, but later moved to biochemistry at PhD in Princeton. During that time, he has made his first impetus: isolating and describing the protein protein "Algae" in Alzheimer's in 1977, as well as "Chronic Traumatic Encephalopathy" (CTE) by boxer and soccer players.
Later, he was able to explain the complex mechanism of cell division in the fundamental process of biology.
Her career has been so successful. And it continued at such a rate. He also describes and describes genes for proteins called keratin (hair), actin (muscle), or tubulin (cytoskeleton). Later, he was able to explain the complex mechanism of cell division in the fundamental process of biology. Then only the development of designer DNA drugs against various neurodegenerative diseases.
The 68-year-old young man's latest idea is already going on: Cleveland wants to restore the brain's new nerve cells. Alzheimer's, Parkinson's, or even KTE's infectious diseases kill innumerable cells. Usually, there is a sufficient support cell known as astrocyte, which is easy to distinguish between nerve cells. His team has now been able to use DNA drugs to turn astrocytes into nerve cells. And they were cut properly with the mouse, "says Cleveland. "I have never hoped for that." Apparently, this is different in textbooks.
Created: 16.11.2018, 19:16 hours